Search results for "Secondary Phosphine"
showing 2 items of 2 documents
P-chirogenic secondary phosphine oxides : new synthesis and applications
2015
A new stereoselective synthesis of phosphinous acid boranes is described by hydrolysis of aminophosphines boranes prepared by reaction of the oxazaphospholidine complex derived from ephedrine with organolithium reagents.By reaction with a strong acid, the phosphinous acid boranes lead to the corresponding P-chirogenic secondary phosphine oxides in very good yields (90%) and with complete retention of the configuration at the phosphorus atom. The secondary phosphine oxides have been used in asymmetric hydrogenation and intramolecular Heck cyclisation using rhodium and palladium complexes, respectively. In a second part, a new synthesis of P-chirogenic ortho-halogenophenyl phosphine oxides is…
Synthèse de mono et diphosphines dérivées d'amino acides ou de peptides, appliquées en chimie de coordination et pour le greffage de fullerène C60
2013
The synthesis of secondary phosphine borane amino acids or dipeptides and their applications for the preparation of chiral ligands or for the grafting of fullerene, is described. These compounds were synthesized in good yield (up to 98%) without racemization. The principle of the synthesis is based on the alkylation of primary phosphine borane with a γ-iodo amino acid using phase transfer conditions. Tertiary diphosphine amino acids are obtained with 70% yield after a second alkylation. These compounds are one of the first examples of diphosphine grafted with a P-C bond on the side chain of amino acid. First of all, mono and diphosphine amino acid derivatives were used in asymmetric allylic…